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PD STAT - Simvastatin as a neuroprotective treatment for Parkinson’s disease

Simvastatin is a cholesterol lowering drug which evidence suggests might possibly protect nerve cells in the brain from injury or loss. In this clinical trial, we want to see whether simvastatin has the potential to slow or halt the progression of Parkinson’s disease.

Eligible patients have been randomly allocated to one of two treatment groups: one group has received simvastatin capsules to be taken orally, and the other has received a 'dummy drug'.

Information is being gathered from participants using a variety of questionnaires and practical tests during eight PD STAT clinic visits. Participation in the trial lasts for just over two years.

The trial has closed to recruitment with a total of 235 participants recruited from 23 participating hospitals.

The trial is being led by the Peninsula Clinical Trials Unit at Plymouth University and sponsored by Plymouth Hospitals NHS Trust. The study is being funded by The Cure Parkinson’s Trust and the JP Moulton Charitable Foundation.

Research sites

Site name Site Lead
Derriford Hospital, Plymouth Dr Camille Carroll
Royal Cornwall Hospital, Truro Dr Christine Schofield
Royal Devon & Exeter Hospital Dr Ray Sheridan
Musgrove Park Hospital, Taunton Dr Anita Goff
Yeovil District Hospital Dr Rani Sophia
Christchurch Hospital Dr Khaled Amar
Royal United Hospital, Bath Dr Veronica Lyell
St Peter's Hospital, Chertsey Dr Jan Coebergh
Charing Cross Hospital, London Dr Sophie Molloy
Royal Free Hospital, London Prof Huw Morris
Queen's Hospital, Romford Dr Anjum Misbahuddin
John Radcliffe Hospital, Oxford Dr Sudhir Singh
Luton and Dunstable Hospital Prof Anette Schrag
Addenbrookes Hospital Dr Paul Worth
Salford Royal Hospital Dr Christopher Kobylecki
Fairfield General Hospital, Bury Dr Jason Raw
Royal Preston Hospital Dr Omesh Kulkarni
Leeds General Infirmary Dr Jane Alty
Clinical Ageing Research Unit, Newcastle Professor Nicola Pavese
Kings College Hospital, London Prof Ray Chaudhuri
Royal Hallamshire Hospital, Sheffield Prof Oliver Bandmann
Norfolk and Norwich University Hospital Dr Godwin Mamutse
Rotherham General Hospital Dr Ahmed Hafiz
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